Have you heard about biosafety cabinet malaysia? If you don’t, let me explain! The safe handling of biological materials, especially infectious pathogens, is referred to as biosafety. In order to avoid unintentional exposure to infections and poisons or their unintentional discharge, containment principles, technologies, and practices are discussed. Preventing unauthorized access, loss, theft, abuse, diversion, or purposeful release of priceless biological resources requires responsible laboratory methods, which include security, control, and accountability for those assets.
Considerations while selecting a biosafety cabinet.
Measures to isolate or contain hazardous pathogenic pathogens in a lab are known as biosafety levels. A biological safety officer and institutional biosafety committees may be useful for assessing the risk of hazardous substances. Biosafety levels include:
Biosafety level 1
Is used for teaching laboratories, undergraduate and secondary educational training, other laboratories using non-pathogenic microorganisms, and for research. Examples include the contagious canine hepatitis virus, Naegleria gruberi, and Bacillus subtilis. For handwashing, a sink is all that is needed for BSL-1 containment.
Biosafety level 2
Is suitable for clinical, diagnostic, educational, and other laboratories that work with locally prevalent, moderate-risk compounds that are associated with human disease and that are found in a community. HIV, Salmonella, Toxoplasma, and the Hepatitis B virus are some examples. As long as there is little formation of aerosols, these microbes may be employed on the open bench. By consuming the germs or exposing the mucosal membrane to them, one may become vulnerable to risks. In order to handle contaminated materials safely, some procedures must be taken (i.e. sharp objects). The same goes for procedures involving aerosol, which should be carried out in BSC or safety centrifuge cups. Along with handwashing stations and facilities for waste purification, personal protective equipment is also effective.
Biosafety level 3
Applies to facilities handling domestic or foreign agents with the potential to transmit respiratory infections that can be fatal. Examples include Coxiella burnetii, Mycobacterium tuberculosis, and St. Louis encephalitis virus. Autoinoculation, ingesting harmful substances, and coming into contact with infectious aerosols are all ways that risks might be acquired. Procedures should be carried out in a BSC or a gas-tight aerosol production chamber for containment. To lessen the discharge of dangerous aerosols, ventilation systems should be adequate.
Biosafety level 4
Is suitable for dangerous diseases or hazardous substances that provide a life-threatening threat and may spread by aerosol and do not have a vaccination or treatment. Examples are the hemorrhagic fevers Marburg and Congo-Crimean. By inhaling infectious aerosols, exposing skin membranes to dangerous droplets, or through autoinoculation, one may get exposed to risks. Procedures should be carried out in a Class III BSC or while wearing a full body air supplied positive pressure personnel suit in order to totally isolate the infectious organisms.
The BSL-4 laboratory is housed in a remote building with specialized waste disposal and ventilation systems. A laboratory director should oversee the overall operation of the facility. This will be supplemented by the availability of skilled laboratory workers, safety measures/manuals, safety gear, suitable facility design, personal protection equipment, and biosafety level procedures.